Benefits
- Accelerates tendon, ligament, and muscle healingstrong
- Protects and heals the gastrointestinal lining (leaky gut, IBS, ulcers)strong
- Promotes angiogenesis (new blood vessel formation) at injury sitesstrong
- Neuroprotective effects — may aid recovery from traumatic brain injurymoderate
- Reduces inflammation systemically via nitric oxide modulationmoderate
- May counteract NSAID-induced gut damagestrong
- Potential antidepressant and anxiolytic effects via dopamine system modulationpreliminary
Dosage Protocols
| Route | Dosage Range | Frequency | Notes |
|---|---|---|---|
| Subcutaneous injection | 200–500 mcg | 1–2× daily | Inject near the injury site for localized healing |
| Oral (capsule) | 500–1000 mcg | 1–2× daily | Preferred for gut-related conditions; stable in gastric acid |
| Intramuscular injection | 200–500 mcg | 1× daily | Alternative to subcutaneous for systemic effects |
Medical disclaimer
Dosage information is provided for educational reference only. Always follow your prescriber's instructions and consult a qualified healthcare provider before starting any peptide protocol.
Side Effects
- Nausea (usually transient, first few doses)common
- Injection site redness or irritationcommon
- Dizziness or lightheadednessrare
- Headacherare
- Theoretical concern about promoting growth in existing tumors (no clinical evidence)serious
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Articles
- BPC-157: The Complete Guide to Body Protection Compound-157A comprehensive guide to BPC-157, the gastric pentadecapeptide studied for healing tendons, ligaments, gut lining, and more. Covers mechanism of action, evidence levels, administration routes, and what the preclinical research actually shows.
- BPC-157 Benefits: Evidence-Based Breakdown of Research FindingsDeep dive into BPC-157 benefits with evidence ratings for each use case. Covers tendon healing, gut repair, neuroprotection, inflammation reduction, and more — all grounded in published preclinical research.
- BPC-157 Dosage: What Research and Clinical Practice SuggestEducational overview of BPC-157 dosing ranges discussed in research literature and clinical practice. Covers subcutaneous, oral, and intramuscular protocols, dose-response considerations, and why uncertainty remains without human trial data.
- BPC-157 Side Effects: Safety Profile from Research DataWhat does the research say about BPC-157 side effects? Covers common anecdotal reports (nausea, injection site irritation), theoretical risks (VEGF-mediated tumor growth), drug interactions, and the critical limitations of preclinical-only safety data.
Frequently Asked Questions
Is BPC-157 FDA approved?
No. BPC-157 has not been evaluated or approved by the FDA for any medical condition. All evidence is from preclinical (animal) studies. It is sold as a research chemical, not a pharmaceutical.
Can I take BPC-157 orally instead of injecting?
Yes. BPC-157 is uniquely stable in gastric acid, making oral administration viable — especially for gut-related conditions. However, subcutaneous injection near an injury site is generally preferred for musculoskeletal healing, as it delivers a higher local concentration.
How long does BPC-157 take to work?
Most anecdotal reports note initial improvements within 1–2 weeks, with significant healing by 4–6 weeks. The timeline depends heavily on the injury type and severity. Tendon injuries typically take longer than muscle injuries.
Can BPC-157 be stacked with TB-500?
Yes. BPC-157 and TB-500 are commonly stacked for healing protocols. BPC-157 promotes localized repair and angiogenesis, while TB-500 upregulates actin and supports systemic tissue repair. They work through complementary mechanisms.
Does BPC-157 need to be refrigerated?
Reconstituted BPC-157 should be refrigerated at 2–8°C (36–46°F) and used within 30 days. Unreconstituted (lyophilized) powder can be stored at room temperature but lasts longer refrigerated.
References
- 1Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts(2010)PubMed ↗
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Last updated: 2026-02-14